Table 3.

Body weights, tissue weights, caloric intake and surrogate markers for insulin resistance in mice that had been fed an ad libitum high fat diet for 9 weeks, and after 1 week recovery from phlebotomy had been switched to the intervention diets for another 9 weeks.

	RLF (n=5)	RHF-P (n=5)	RHF (n=5)
	19 weeks	19 weeks	19 weeks
Body weight gain (g)	−6.8 ± 0.9 **	0.3 ± 1.1	11.3 ± 0.8 ***
Liver weight (g)	0.98 ± 0.06 ***	1.63 ± 0.07	3.52 ± 0.40 **
Liver/body weight ratio	0.034 ± 0.00 ***	0.044 ± 0.00	0.072 ± 0.01 **
Total caloric intake / mouse (kcal)	468	492	754
Caloric efficiency (g/kcal)	−0.0145	0.0006	0.0150
Relative Inguinal fat mass (%)	3.73 ± 0.72 **	7.37 ± 0.58	9.36 ± 0.48 *
Mesenteric fat pad (%)	1.91 ± 0.29 **	3.50 ± 0.23	4.38 ± 0.14 *
Retroperitoneal fat pad (%)	1.67 ± 0.35 *	2.74 ± 0.26	4.32 ± 0.24 **
Epidydimal fat pad (%)	4.56 ± 0.61 ***	8.44 ± 0.45	12.28 ± 0.70 **
White adipose tissue fat index (%)	11.87 ± 1.92 **	22.05 ± 1.40	29.33 ± 1.36 **
Fasting glucose (mg/dL)	204 ± 8	250 ± 15	252 ± 11
Fasting insulin (μU/mL)	16.9 ± 2.2 **	72.6 ± 7.1	90.4 ± 13.8
QUICKI	0.28 ± 0.01 ***	0.24 ± 0.00	0.23 ± 0.00
HOMA	8.6 ± 1.3 **	44.5 ± 5.6	57.2 ± 11.2
Log(HOMA)	0.91 ± 0.07 ***	1.63 ± 0.06	1.72 ± 0.09

Values given are means ± SEM; RHF-P group was used as reference;

^*P<0.05;

^**P<0.01;

^***P<0.001.

RLF indicates reversal low fat; RHF-P, reversal high fat pair-fed; RHF, reversal high fat; QUICKI, quantitative insulin-sensitivity check index; HOMA, homeostasis model assessment.