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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Nat Rev Drug Discov. 2011 Jun;10(6):453–471. doi: 10.1038/nrd3403

Figure 4. The p47phox tandem-repeat SH3 domain as a potential drug target.

Figure 4

Nuclear magnetic resonance solution structure of the p22phox proline-rich region (PRR)-binding domain formed by the tandem repeat Src homology (SH3) domain of p47phox before (a) and after (b) molecular modelling to rotate a putative dynamic tryptophan residue (Trp193) within its core. Note that rotation of Trp193 results in two smaller pockets (red and orange) combining to form a single large pocket that is potentially druggable.