Table 3.
Comparison of subunit utilization of the seven NADPH oxidases
| NOX1 | NOX2 | NOX3 | NOX4 | NOX5 | DUOX1 | DUOX2 | |
|---|---|---|---|---|---|---|---|
| p22phox | + | + | + | + | − | − | − |
| DUOXA1 | − | − | − | − | − | + | + |
| DUOXA2 | − | − | − | − | − | + | + |
| p67phox | − | + | − | − | − | − | − |
| NOXA1 | + | − | +* | − | − | − | − |
| p47phox | +‡ | + | − | − | − | − | − |
| NOXO1 | +§ | − | +* | − | − | − | − |
| p40phox | − | + | − | − | − | − | − |
| POLDIP2 | ND | ND | ND | + | ND | ND | ND |
| RAC1 | + | + | + | − | − | − | − |
| RAC2 | − | + | − | − | − | − | − |
DUOXA1, dual oxidase activator 1; NOXA1, NADPH oxidase activator 1; NOXO1, NOX organizer 1; ND, not determined; POLDIP2, polymerase δ-interacting protein 2.
*
NOX3 is constitutively active when it forms a complex with p22phox; however, its activity is further elevated by NOXA1 and NOXO1 subunits (REF. 227).
‡
Expressed with NOX1 in vascular smooth muscle cells only.
§
Not detectable in vascular smooth muscle cells.