Fig. 4.

Changes in prefrontal cortical BOLD signal changes with pregestational cocaine sensitization. Lactating rats showing the lower prefrontal BOLD signal response to suckling were cocaine sensitized (black bar and 3D map on the right). A pictorial representation of the role of the medial prefrontal cortical regions in maternal responses and maternal behavior is shown to the lower right, below maps. The image is not intended to represent the synaptic physiology of the cortex, but instead to represent the integration of various sensory stimuli from pups in the cortex and the behavioral outcomes mediated through the prefrontal cortex.