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. Author manuscript; available in PMC: 2012 Jul 20.
Published in final edited form as: Drug Discov Today Dis Mech. 2011 Jul 20;8(1-2):e9–e14. doi: 10.1016/j.ddmec.2011.06.001

Table 1.

Suggested improvements for various types of donation and storage.

Type of PlateletAcquisition When used Adverse Events Possible Areas for Improvement
Single Donor Pheresis Platelets Thrombocytopenia

  • Loss of platelet hemostatic properties over storage time

  • increase of soluble prothrombotic and inflammatory mediators over storage time

  • ABO incombatibilites

  • HLA incompatibilities

  • Washing

  • Leukoreduction

  • Platelet activity suppression therapy

  • Decrease storage time
Whole Blood Pooled Platelets

  • Non-identical blood type pooling

  • Increased risk of bacterial contamination