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. Author manuscript; available in PMC: 2013 May 2.
Published in final edited form as: Cell Metab. 2012 May 2;15(5):665–674. doi: 10.1016/j.cmet.2012.04.004

FIGURE 1.

FIGURE 1

mRNA expression of key genes associated with hepatic cholesterol metabolism. (A): obese normal controls had the same level of expression of HMGCR, SREBP-2, LDLR and LAL as lean normal controls. However, both NAFL and NASH were associated with a significantly increased HMGCR (* p< 0.001 for both vs. either control) and LAL (* p< 0.002 for both vs. either control) expression and decreased LDLR expression (* p< 0.01 for both NAFL or NASH vs. either control), (B): NAFL and NASH were associated with significantly elevated nCEH expression (* p< 0.0001 for both vs. lean or obese controls). Obese controls, NAFL and NASH had a significantly increased CYP7A expression compared to lean controls (* p< 0.02), (C): Compared to lean and obese normal controls which were similar, NAFL and NASH were associated with a significant decrease in expression of ABCA1, ABCG1 and ABCG8 (* p< 0.05 for all). Mean ± S.D. shown for all data.