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A schematic showing the key molecular changes in cholesterol metabolic pathways in NASH compared to lean or obese controls. Increased HMGCR and nCEH expression would be expected to increase the FC pool. Utilization of FC for bile acid synthesis is decreased due to decreased CYP7A and CYP27A expression. ABCG1 and ABCG8 expression are also decreased which would be expected to decrease export of cholesterol from hepatocytes.
