Skip to main content
. 2012 Feb 15;302(9):C1405–C1412. doi: 10.1152/ajpcell.00435.2011

Fig. 6.

Fig. 6.

Localization of the P425 residue based on a homology model and the 2-dimensional topology of PCFT. Top: confirmed topology of PCFT (36) indicating the external location of the P425 residue at the junction of the 6th external loop and the 12th transmembrane domain (TMD). Bottom: homology model of PCFT. Bottom left: WT-PCFT, looking into the aqueous translocation pathway from the extracellular compartment. Bottom right: P425R-PCFT, looking into the aqueous translocation pathway from the extracellular compartment. The P425 residue is indicated in yellow; the K422 residue is indicated in blue.