. Author manuscript; available in PMC: 2013 May 25.

Published in final edited form as: J Nat Prod. 2012 Apr 24;75(5):883–889. doi: 10.1021/np200940b

Table 3.

Antiplasmodial Activity of Compounds 5–7 and 10c

Compound	Chloroquine-sensitive (D6)-clone		Chloroquine-resistant (W2)-clone		Cytotoxicity to Vero cells

	IC₅₀ μM	S.I.	IC₅₀ μM	S. I.	IC₅₀ μM
5	1.08	4.8	1.62	3.2	5.24
6	2.78	1.9	3.12	1.7	5.21
7	2.75	1.6	1.94	2.3	4.53
10c	6.76	>1.1	6.51	>1.2	NC
chloroquine^a	0.03		0.31		NC
artemisinin^a	0.02		0.01		NC

Positive controls

NC not cytotoxic

S. I. (selectivity index) = IC₅₀ for cytotoxicity/IC₅₀ for antiplasmodial activity

IC₅₀: concentration causing 50% growth inhibition