Table 2.
HPA-related gene expression in hypothalamus following 6 days of intracerebroventricular fluoxetine infusion
| Nonpregnant |
Pregnant |
|||
|---|---|---|---|---|
| Gene | Vehicle | Fluoxetine | Vehicle | Fluoxetine |
| GR | 1.12 ± 0.22 | 0.90 ± 0.15 | 0.94 ± 0.05 | 0.75 ± 0.07 |
| MR | 1.12 ± 0.30 | 0.66 ± 0.17 | 2.05 ± 0.07 | 1.23 ± 0.31 |
| CRH | 1.38 ± 0.62 | 4.03 ± 1.65 | 3.90 ± 1.27 | 4.49 ± 1.35 |
| AVP | 2.21 ± 1.53 | 2.49 ± 0.82 | 4.07 ± 0.84 | 4.02 ± 1.06 |
| 5-HT1A | 1.20 ± 0.38 | 0.76 ± 0.20 | 0.70 ± 0.13 | 0.64 ± 0.11 |
| 5-HT2A | 1.12 ± 0.21 | 1.17 ± 0.23 | 1.39 ± 0.25 | 0.88 ± 0.16 |
| POMC | 1.31 ± 0.61 | 2.27 ± 1.36 | 0.44 ± 0.13* | 0.35 ± 0.04* |
| NPY | 1.41 ± 0.35 | 1.76 ± 0.41 | 1.54 ± 0.41 | 1.20 ± 0.22 |
Values (means ± SE) are expressed as fold change relative to nonpregnant control ewes. NPY, neuropeptide Y.
Significantly different from ΔCt of nonpregnant control group (P < 0.05).