Table 2.
The proline-rich motif (PRM) and the proline-rich motif binding (PRB) domain in immune-related proteins.
| Protein receptor | PRM | PRM interactant | PRD critical residue | Evidence | |
|---|---|---|---|---|---|
| Membrane associated | CD28 | MYPPPY | CD80 | Y71 | Mutagenesis |
| CD152 | MYPPPY | CD86 | F | Mutagenesis, structural analysis | |
| ICOS | FDPPP | ICOSL | Y53 | Mutagenesis, molecular model | |
|
| |||||
| Cytoplasmic | WIP | LPPP | WASP | WHI1 domain, W54 | Structural analysis |
|
| |||||
| Signal transduction | GILZ | PXX | p65 | TAD (F534. F542) | Immunoprecipitation |
|
| |||||
| Transcriptional cofactors | p53 | PXXP | p300 | (SPC1 192–337) SPC-2 (1737–1913) | ChIP |
| SMRT | PXLXP | p65 | TAD | GST pull-down assays | |
| SMRT | MCTF | MYND domain | Mutagenesis | ||
| EA1 | MYND domain | Solution structure | |||
| ETO | MYND domain | Solution structure | |||
Myc-related cellular transcription factor; viral oncoproteins EA1; ETO (a nuclear corepressor protein) chromatin immunoprecipitation.