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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Stroke. 2011 Jun 30;42(8):2308–2314. doi: 10.1161/STROKEAHA.110.608547

Figure 2. MCAO-induced brain injury was exacerbated in MRP1 deficient mice.

Figure 2

Transient focal cerebral ischemia was induced in MRP1 deficient (n=20) or FVB mice (n=15) by MCAO. A, MRP1 KO mice presented larger stroke-induced lesion compared to FVB mice after 48h reperfusion (FVB, n=8; MRP1 KO, n=12). B, Protein expression of MRP1 was increased in infarct hemisphere of FVB mice (n=3). C, MRP1 deficient mice contained significantly higher level of GSSG in stroke-affected hemisphere compared to that of FVB mice (n=4). *P<0.05 compared with corresponding contralateral hemisphere; †P<0.05 compared with FVB; §P<0.05 compared with infarct hemisphere of FVB.