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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Stroke. 2011 Jun 30;42(8):2308–2314. doi: 10.1161/STROKEAHA.110.608547

Figure 5. Orally supplemented α-tocotrienol protected against stroke via MRP1 upregulation.

Figure 5

C57BL/6 mice were orally gavaged with vitamin E-stripped corn oil (n=18) or 50mg α-TCT per kg body weight (n=23) for 13 weeks then MCAO was performed. A, α-TCT supplementation significantly reduced MCAO-induced brain injury (corn oil supplemented mice, n=9; α-TCT supplemented mice, n=10). miR-199a-5p expression was significantly down-regulated (B) while MRP1 mRNA (C) and protein (D) levels were significantly elevated in the stroke affected tissue of α-TCT fed mice (n=3). *P<0.05 compared with corresponding control; §P<0.05 compared with infarct hemisphere of corn oil fed mice.