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Compared with PBS-injected brains, those brains injected with Aβ or with H2O2 had a significant increase in free radical levels in mitochondria, according to the CM-H2XROS/MitGreen quotient (*P < 0.05 versus all the other groups). However, by using melatonin a significant decrease in mitochondrial free radicals was observed both in Aβ- and in H2O2-injected brains.
