Fig. 4.

Injection of insulin+hypertonic dextrose decreases Na⁺, K⁺, and H₂O excretion, and glomerular filtration rate. Rats were injected (ip) with 1 ml of either water or insulin in 50% dextrose solution. Urine was collected over two 2-h periods. A: Na⁺ excretion. B: K⁺ excretion. C: volume excretion. D: creatinine clearance was measured from the rate of creatinine excretion during the final 2-h period and the concentration of creatinine in plasma at the end of this collection. *Statistical significance (P < 0.05 vs. control values).