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Inhibition of ligand-induced FXR target gene expression in Set7/9-silenced Huh-7 cells. Set7/9 expression was markedly and specifically reduced compared with control in RNAi-transfected cells at both the protein (A) and mRNA level (B). C: SHP and BSEP mRNAs declined significantly, as assessed by real-time quantitative PCR. *P < 0.05, #P < 0.001.
