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. 2012 Feb 16;302(9):G925–G936. doi: 10.1152/ajpgi.00263.2011

Fig. 4.

Fig. 4.

Hepatic bile acid transporter genes are differentially regulated in Nrf2−/− mice. A: relative mRNA expression of multidrug resistance-associated protein (Mrp3 and Mrp4), organic solute transporter (Ostα), bile salt export pump (Bsep), multidrug resistance (Mrp2), sodium-taurocholate-cotransporting polypeptide (Ntcp), and organic anion-transporting polypeptide (Oatp1a1) in liver of wild-type and Nrf2−/− mice. Data are expressed as fold change relative to wild-type mice. Values are means ± SD of 5–6 animals. B: immunoblots of membrane-enriched fractions from wild-type and Nrf2−/− mouse liver for Mrp3, Mrp4, Ostα, Bsep, Mrp2, Ntcp, and Oatp1a1. Values represent ratio of protein expression in wild-type mice to that in Nrf2−/− mice. Data are normalized to Src homology 2 domain-containing protein tyrosine phosphatase (SH-PTP1) and expressed in arbitrary units. Values are means ± SD of 5–6 individual animals in each group. Amount of protein from wild-type mice is set as 100. *P < 0.05. **P < 0.01. ***P < 0.001.