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. 2012 Feb 16;302(9):G925–G936. doi: 10.1152/ajpgi.00263.2011

Fig. 5.

Fig. 5.

Downregulation of intestinal apical sodium-dependent bile acid transporter (Asbt), Fxr, Fgf15, ileal bile acid-binding protein (Ibabp), and Ostα in Nrf2−/− mice results in increased fecal bile acid excretion. A and B: expression of membrane transporter gene (Abst) and protein expression of Asbt in ileum of wild-type and Nrf2−/− mice. SH-PTP1 was used as an internal control, and densitometry was performed using the Li-Cor Odyssey infrared imaging system. Data are expressed as arbitrary units. Values are means ± SD of 5–6 animals. Amount of protein from wild-type mice is set as 100. C: fecal bile acid levels. Altered enterohepatic circulation in Nrf2−/− mice results in more fecal excretion of bile acids in Nrf2−/− mice. D: relative mRNA expression for Fxr, Fgf15, Ibabp, and Ostα from ileum of wild-type and Nrf2−/− mice. Data are expressed as fold change relative to wild-type mice. Values are means ± SD of 5–6 animals. Amount of mRNA from wild-type mice is set as 1. *P < 0.05. ***P < 0.001.