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Cyp3a11, a phase I detoxifying enzyme involved in hydroxylation of bile acids, and its activating nuclear receptor pregnane X receptor (Pxr) are augmented in Nrf2−/− mice and after BDL. Data are expressed as fold change relative to sham-operated wild-type mice. Car, constitutive androstane receptor. Values are means ± SD of 5–6 animals. Amount of mRNA from wild-type mice is set as 1. Multiple comparisons were made. *P < 0.05.
