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K-ras downregulates Bmp4 through transcriptional mechanisms in an ERK dependent manner. A: SW480sicontrol and SW480siKrasV12 cells were transfected with the 3.36-kb Bmp4-luc reporter construct and luciferase activity was measured. Cotransfection with a dnERK plasmid or control vector (empty) was performed, and induction of Bmp4 luciferase activity was seen in SW480sicontrol (B) but not SW480siKrasV12 (C) cells. Mean values of 3 independent transfections are shown.
