Table 5.
Putative membrane biomarkers of Sox9-EGFP Low ISC
| Symbol | Gene Name | Fold Change | ID |
|---|---|---|---|
| PCDH8 | protocadherin 8 | 22.12 | 18530 |
| LGR5* | leucine-rich repeat containing G protein-coupled receptor 5 | 11.72 | 14160 |
| SCN2B* | sodium channel. voltage-gated. type II. beta | 10.44 | 72821 |
| TNFRSF19* | tumor necrosis factor receptor superfamily. member 19 | 10.08 | 29820 |
| OR1S1 | olfactory receptor. family 1. subfamily S. member 1 | 8.58 | 258991 |
| GPM6B | glycoprotein M6B | 8.51 | 14758 |
| CXCR7 | chemokine (C-X-C motif) receptor 7 | 7.94 | 12778 |
| SLCO3A1* | solute carrier organic anion transporter family. member 3A1 | 7.01 | 108116 |
| Olfr361 | olfactory receptor 361 | 6.96 | 258365 |
| PTPRO* | protein tyrosine phosphatase. receptor type. O | 6.73 | 19277 |
| RGMB* | RGM domain family. member B | 6.55 | 68799 |
| FAIM2 | Fas apoptotic inhibitory molecule 2 | 6.20 | 72393 |
| AQP4* | aquaporin 4 | 5.63 | 11829 |
| KCNA3 | potassium voltage-gated channel. shaker-related subfamily. member 3 | 4.52 | 16491 |
| Vmn1r171 (includes others) | vomeronasal 1 receptor 171 | 4.50 | 100043103 |
| TBC1D9 | TBC1 domain family. member 9 (with GRAM domain) | 4.18 | 71310 |
| PODXL2 | podocalyxin-like 2 | 3.30 | 319655 |
| OR1B1 | olfactory receptor. family 1. subfamily B. member 1 | 3.18 | 259053 |
| CD320 | CD320 molecule | 3.01 | 54219 |
| ADAM8 | ADAM metallopeptidase domain 8 | 2.73 | 11501 |
| FGFRL1* | fibroblast growth factor receptor-like 1 | 2.62 | 116701 |
| Olfr190/Olfr192 | olfactory receptor 192 | 2.60 | 258392 |
| GAS1 | growth arrest-specific 1 | 2.51 | 14451 |
| PARD6G | par-6 partitioning defective 6 homolog gamma (C. elegans) | 2.29 | 93737 |
| TRIB2 | tribbles homolog 2 (Drosophila) | 2.29 | 217410 |
| TNFRSF25 | tumor necrosis factor receptor superfamily. member 25 | 2.23 | 85030 |
| SIGLEC7/SIGLEC9 | sialic acid binding Ig-like lectin 7 | 2.20 | 83382 |
| OFD1 | oral-facial-digital syndrome 1 | 1.80 | 237222 |
| Vmn1r188 (includes others) | vomeronasal 1 receptor 194 | 1.71 | 171257 |
| TMPRSS4 | transmembrane protease. serine 4 | 1.51 | 214523 |
Fold change is expressed vs. gene expression in Sox9-EGFP Negative cells (n = 7; P < 0.05). Thirty genes coding for membrane proteins were specifically and significantly upregulated in Sox9-EGFP Low cells vs. all other Soc9-EGFP cells [
*
8 genes previously reported as enriched in Lgr5-EGFPhi ISCs (65)].