Table 7.
Oxidative phosphorylation-related genes regulated by irradiation specifically in Sox9-EGFP High cells
| Symbol | Gene Name | Fold Change | ID |
|---|---|---|---|
| COX7A1 | cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) | −2.95 | 12865 |
| ATP6V1B2 | ATPase, H+ transporting, lysosomal 56/58 kDa, V1 subunit B2 | −2.87 | 11966 |
| ATP6V0E2 | ATPase, H+ transporting V0 subunit e2 | −2.53 | 76252 |
| ATP6V0B | ATPase, H+ transporting, lysosomal 21 kDa, V0 subunit b | −2.51 | 114143 |
| ATP6V0A1 | ATPase, H+ transporting, lysosomal V0 subunit a1 | −2.32 | 11975 |
| ATP6V1G1 | ATPase, H+ transporting, lysosomal 13 kDa, V1 subunit G1 | −2.26 | 66290 |
| ATP6AP1 | ATPase, H+ transporting, lysosomal accessory protein 1 | −2.18 | 54411 |
| ATP6V1E1 | ATPase, H+ transporting, lysosomal 31 kDa, V1 subunit E1 | −2.00 | 11973 |
| ATP6V0D1 | ATPase, H+ transporting, lysosomal 38 kDa, V0 subunit d1 | −1.95 | 11972 |
| ATP6V1H | ATPase, H+ transporting, lysosomal 50/57 kDa, V1 subunit H | −1.84 | 108664 |
| ATP6V1G2 | ATPase, H+ transporting, lysosomal 13 kDa, V1 subunit G2 | −1.78 | 66237 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14 kDa, V1 subunit F | −1.56 | 66144 |
| ATP5G1 | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) | −1.43 | 11951|100041835 |
| NDUFB7 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18 kDa | −1.38 | 66916 |
| ATP5B | ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide | −1.34 | 11947 |
| TCIRG1 | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 | −1.29 | 27060 |
| NDUFB9 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22 kDa | −1.28 | 66218 |
| NDUFS5 | NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15 kDa (NADH-coenzyme Q reductase) | −1.28 | 595136 |
| NDUFB10 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22 kDa | −1.27 | 68342 |
| UQCRQ | ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5 kDa | −1.25 | 22272 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | −1.24 | 67530 |
| NDUFB3 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12 kDa | −1.19 | 66495 |
| NDUFA5 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13 kDa | −1.13 | 68202 |
| COX7B | cytochrome c oxidase subunit VIIb | 1.21 | 66142 |
| NDUFA8 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19 kDa | 1.23 | 68375 |
| CYC1 | cytochrome c-1 | 1.36 | 66445 |
| NDUFC2 | NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5 kDa | 1.41 | 68197 |
| COX6B2 | cytochrome c oxidase subunit VIb polypeptide 2 (testis) | 1.48 | 333182 |
| NDUFA10 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42 kDa | 1.51 | 67273 |
| NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8 kDa | 1.64 | 100043472|70316 |
Sox9-EGFP High cells undergo a shift of gene expression profiling toward a stem cell-like phenotype. IPA (Ingenuity Pathway Analysis) of the 2,071 genes differentially regulated after irradiation only in Sox9-EGFP High cells revealed that 30 genes were significantly related to oxidative phosphorylation signaling pathway (P < 0.0001), 23 of 30 being repressed (bold font). Fold change is expressed vs. gene expression in Sox9-EGFP High cells isolated from nonirradiated mice (n = 3–7).