Table 8.
p53 Signaling-related genes regulated by irradiation specifically in Sox9-EGFP High cells
| Symbol | Gene Name | Fold Change | ID |
|---|---|---|---|
| GADD45A | growth arrest and DNA-damage-inducible, alpha | −3.32 | 13197 |
| MAPK14 | mitogen-activated protein kinase 14 | −2.63 | 26416 |
| CCND2 | cyclin D2 | −2.21 | 12444 |
| TP63 | tumor protein p63 | −1.96 | 22061 |
| CASP6 | caspase 6, apoptosis-related cysteine peptidase | −1.95 | 12368 |
| PLAGL1 | pleiomorphic adenoma gene-like 1 | −1.89 | 22634 |
| RRM2B | ribonucleotide reductase M2 B (TP53 inducible) | −1.84 | 382985 |
| HDAC1 | histone deacetylase 1 | −1.61 | 433759 |
| HIPK2 | homeodomain interacting protein kinase 2 | −1.35 | 15258 |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | 1.23 | 11651 |
| CCNK | cyclin K | 1.29 | 12454 |
| STAG1 | stromal antigen 1 | 1.33 | 20842 |
| CDK4 | cyclin-dependent kinase 4 | 1.71 | 12567 |
| LRDD | leucine-rich repeats and death domain containing | 1.77 | 57913 |
| APAF1 | apoptotic peptidase activating factor 1 | 1.90 | 11783 |
| CCND1 | cyclin D1 | 2.43 | 12443 |
| TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a | 2.76 | 21933 |
| TOPBP1 | topoisomerase (DNA) II binding protein 1 | 2.93 | 235559 |
| CHEK2 | CHK2 checkpoint homolog (S. pombe) | 3.04 | 50883 |
Sox9-EGFP High cells undergo a shift of gene expression profiling towards a stem cell-like phenotype. IPA analysis of the 2,071 genes differentially regulated after irradiation only in Sox9-EGFP High cells revealed that 19 genes were significantly related to p53 signaling (P < 0.001). Fold change is expressed vs. gene expression in Sox9-EGFP High cells isolated from nonirradiated mice (n = 3–7).