Table 9.

Cell fate/early progenitor markers regulated by irradiation in Sox9-EGFP High cells

Symbol	Description	Fold Change	P Value
KLF7	Kruppel-like factor 7 (ubiquitous)	−2.20	0.028
HES2	hairy and enhancer of split 2 (Drosophila) (Hes2)	−1.55	0.014
NEUROG1	neurogenin 1	−1.29	0.006
HES5	hairy and enhancer of split 5 (Drosophila) (Hes5)	1.68	0.042
ATOH1	atonal homolog 1 (Drosophila) (Atoh1)	2.73	0.023
SPDEF	SAM pointed domain containing ets transcription factor (Spdef)	3.68	0.018
NEUROG3	neurogenin 3 (Neurog3)	3.77	0.020

Sox9-EGFP High cells undergo a shift of gene expression profiling towards a stem cell-like phenotype. Seven genes coding for markers of cell fate specification/early progenitors were regulated specifically in Sox9-EGFP High cells during crypt regeneration. Fold change is expressed vs. gene expression in Sox9-EGFP High cells isolated from nonirradiated mice (n = 3–7).