Fig. 1.

Genetic deficiency of P2X7 decreases hepatic necrosis and inflammation in acetaminophen (APAP)-induced acute liver injury. Wild-type (WT; n = 6) and P2X7−/− mice (n = 7) were administered APAP at 500 mg/kg ip for 6 and 12 h. WT (n = 2) and P2X7−/− mice (n = 2) were also given PBS as control groups. Liver histology was assessed 12 h at posttreatment (A and B), serum ALTs at 6 h posttreatment (C), and neutrophils in the liver at 12 h posttreatment (D and E) . NS, not significant; *P < 0.05. Arrows point to neutrophils.