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Genetic deficiency of CD39 accelerates hemorrhage and increases mortality in APAP hepatotoxicity. WT (n = 6) and CD39−/− mice (n = 6) were administered APAP at 200 mg/kg ip. Liver histology was assessed at 12 h post-APAP treatment (A and B). Survival was assessed to 72 h in WT (n = 8) and CD39−/− mice (n = 8) administered APAP at 500 mg/kg ip (C). *P < 0.05.
