Table 3.

Proteins whose O-GlcNAc modification state changes in response to stress or injury

Protein and Site	Stress/Injury	Tissue/Organism	Reference
Carm1	Heat stress	Cos-7 cells	(194)
Cytokeratin 8/18	Heat stress	Cos-7 cells	(93)
DNA PK	Heat stress, ER Stress	Cos-7 cells	(194)
Histone H2B	Heat stress	HeLa cells
IRS-1	Urea (20 mM), probably working through increased ROS	3T3-L1 adipocytes	(31)
Neurofilament H	Glucose deprivation	Neuro-2A	(19)
NF90 and NF110	Heat stress	Cos-7 cells	(194)
Nup153	Heat stress	Cos-7 cells	(194)
P125i (Associates with Sec23)	Heat stress	Cos-7 cells	(194)
Sec24b	Heat stress	Cos-7 cells	(194)
WNK1	Heat stress	Cos-7 cells	(194)

Recently 2 screens have focused on identifying proteins whose O-GlcNAcylation status responds to cellular injury (heat stress, hydrogen peroxide, hypoxia, urea, and trauma hemorrhage). Such proteins are listed here only if their O-GlcNAcylation status was confirmed either by immunoblot or the O-GlcNAc-peptide linkage was confirmed by mass spectrometry. Carm1, coactivator-associated arginine methyltransferase 1; DNA PK, DNA protein kinase; IRS-1, insulin receptor substrate 1; Nup153, nuclear pore protein 153; WNK1, with no lysine kinase 1.