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. 2012 Mar 23;302(10):H2112–H2121. doi: 10.1152/ajpheart.00339.2011

Fig. 2.

Fig. 2.

Gross morphology and histology of hearts in different treatment groups of animals at 4 wk after treatment. A: terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining of histological section on day 3 after treatment. The number of TUNEL+ cells was significantly lower in Ad-shPDE5A-treated group 2 compared with Ad-Null-treated animal hearts. B: transverse ventricular sections of mice hearts treated with DMEM, Ad-Null, and Ad-shPDE5a. Sections were stained with Masson's trichrome. Note the smaller LV cavity, shorter infarct segments, and thicker infarct walls in Ad-shPDE5a-treated heart. C: salvaged cardiomyocytes (residual cardiomyocytes) in the infarcted wall of hearts from different treatment groups stained with Masson's trichrome. Islands of abundant viable cardiomyocytes were observed in the infarcted wall of Ad-shPDE5a-treated mice. Magnification ×1000. D: infarct size and fibrosis were significantly reduced in Ad-shPDE5a-treated mice. Values are means ± SE. *P < 0.05 vs. Ad-Null-treated mice; #P < 0.05 vs. DMEM-treated mice.