Figure 2.

In animals, P-loop cation conduction pathways are known to be formed from four P-loops in an “inverted teepee” structure stretching across the membrane. Shown is an example of a pore structure generated from the corresponding regions of four A. thaliana CNGC2 polypeptides illustrating the “inverted teepee” conformation formed by four P-loops arranged symmetrically. Ca²⁺ ions are shown moving through the conduction pathway of the channel.