Fig. 2.

Pulmonary venous CoQ₁H₂ efflux rates when CoQ₁ is infused into the pulmonary arterial inflow of NQO1^+/+ or NQO1^−/− lung and effects of rotenone in the lung perfusate or exposure of the mice to hyperoxia. A and B: CoQ₁H₂ efflux rates in NQO1^+/+ and NQO1^−/− lungs. C and D: CoQ₁ concentration ([CoQ₁]) in the perfusion reservoir (infusion concentration) for NQO1^+/+ and NQO1^−/− lungs. E and F: percentage of infused CoQ₁ that appears as [CoQ₁] + CoQ₁H₂ concentration ([CoQ₁H₂]) in the venous effluent for NQO1^+/+ and NQO1^−/− lungs. Values are means ± SE; n = 10 room air-exposed lungs, 4 room air-exposed lungs with rotenone added to the lung perfusate, and 6 hyperoxia-exposed lungs (A, C, and E) and 8 room air-exposed lungs, 4 room air-exposed lungs with rotenone added to the lung perfusate, and 5 hyperoxia-exposed lungs (B, D, and F). Significantly different (by ANOVA and Tukey's honestly significant difference test) within A or within B: *P < 0.05 vs. genotype-matched control room air-exposed lungs; †P < 0.05 vs. genotype-matched rotenone-treated lungs; ‡P < 0.05 vs. hyperoxia-exposed NQO1^+/+ lungs. There were no significant differences (ANOVA) between values within any group (C–F) or between groups (C and D or E and F).