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. 2012 May 1;302(9):F1210–F1223. doi: 10.1152/ajprenal.00660.2011

Fig. 5.

Fig. 5.

A: Western blots of IRI kidneys and controls probed for phospho-JNK (pJNK), JNK, phospho-c-Jun (p-c-Jun), and c-Jun. B and C: two-color IF for phospho-c-Jun and vimentin in area with tubules that recovered normal structure (B) and fibrotic area with defective tubules (C). Nuclear phospho-c-Jun associates with epithelial vimentin staining. Interstitial fibroblasts also express vimentin. D, E, and F: nuclear phospho-c-Jun in 14-day control (D), 14-day IRI kidney treated with vehicle (E), and 14-day IRI kidney treated with SD208 (F). G, H, and I: IHC for ksp-cadherin, PTEN, and phospho-c-Jun in serial sections of 14-day IRI kidney (vehicle-treated). Nuclear phospho-c-Jun is present only in tubules with diminished PTEN and ksp-cadherin. Scale bars = 100 μm.