Table 2.

Multivariable associations between AKI and all-cause mortality

Model of AKI	AKI incidence	Deaths/subgroup (% dead)	Adjusted odds ratio of mortality (95% CI)*	AUC
sCr increase				0.93
<0.3 mg/dl (no AKI)	N/A	223/14,882 (1.5%)	referent
≥0.3 mg/dl or to ≥150% of baseline or initiation of dialysis (AKIN stages 1–3)	4,365/19,249 (22.7%)	470/4,365 (10.8%)	4.43 (3.68–5.35)
sCr increase				0.94
<0.3 mg/dl (no AKI)	N/A	223/14,882 (1.5%)	referent
≥0.3 mg/dl or to 150–199% of baseline (AKIN stage 1)	3,042/19,249 (15.8%)	193/3,042 (6.3%)	2.81 (2.24–3.52)
to 200–299% of baseline (AKIN stage 2)	514/19,249 (2.7%)	85/514 (16.5%)	6.69 (4.86–9.20)
to ≥300% of baseline or [sCr ≥4.0 with increase ≥0.5] or initiation of dialysis (AKIN stage 3)	809/19,249 (4.2%)	192/809 (23.7%)	8.36 (6.43–10.87)

AKI stages based upon the AKIN staging system [7].

^*Adjusted for age, sex, race (black/white/other), chronic kidney disease, and ln(UHC expected mortality). AUC = Area under receiver-operating characteristic curve.