Table 3.

AKI and in-hospital all-cause mortality, stratified by primary discharge diagnosis

Model of AKI	Adjusted odds ratio of mortality (95% CI) stratified by primary ICD-9 diagnosis group *
	circulatory (n = 3,723)	respiratory (n = 1,315)	infection (n = 2,790)	injury (n = 2,424)	other (n = 7,135)
sCr increase
<0.3 mg/dl (no AKI)	referent	referent	referent	referent	referent
≥0.3 mg/dl or to ≥150% of baseline or initiation of dialysis	3.76 (2.49–5.69)	3.84 (2.14–6.93)	5.06 (3.45–7.43)	2.71 (1.59–4.60)	4.96 (3.77–6.53)
sCr increase
<0.3 mg/dl (no AKI)	referent	referent	referent	referent	referent
≥0.3 mg/dl or to 150–199% of baseline (AKIN stage 1)	2.42 (1.51–3.90)	1.91 (0.92–3.98)	3.71 (2.36–5.86)	1.62 (0.83–3.15)	2.96 (2.11–4.16)
to 200–299% of baseline (AKIN stage 2) to ≥300% of baseline or [sCr ≥4.0 with increase ≥0.5]	5.10 (2.59–10.05)	11.24 (4.37–28.94)	8.39 (4.20–16.75)	5.23 (2.21–12.43)	7.21 (4.49–11.58)
or initiation of dialysis (AKIN stage 3)	10.16 (5.62–18.37)	6.74 (2.86–15.91)	6.50 (3.89–10.86)	4.80 (2.02–11.40)	9.95 (6.77–14.64)

AKI stages based upon the AKIN staging system [7]. ICD-9 codes for each subgroup are listed in suppl. Appendix 1. ICD-9 codes for infection are based upon Angus et al. [15] and Wang et al. [16].

^*Adjusted for age, sex, race (black/white/other), chronic kidney disease, and ln(UHC expected mortality).