Table 1.

Comparison of referral screening tools

	PAT [38, 39]	RST [41]	FHAT [40]	Six-Point Scale
Ashkenazi Jewish	4 points/lineage	✓	−	4 points
Breast cancer at age 50+	3 points/relative	✓	4 points/mother 3 points/sister 2 points/second- or third-degree relative	2 points/proband 2 points/relative
		≥2 relatives in same lineage
Breast cancer before age 50	4 points/relative	✓	6 points/age 20–29 4 points/age 30–39 2 points/age 40–49	4 points/proband 4 points/relative
Ovarian cancer	5 points/relative	✓		6 points/proband 4 points/other relative
			7 points/mother 4 points/sister 3 points/second- or third-degree relative Age of onset: 6 points/age <40 4 points/age 40–60 2 points/age >60
Male breast cancer	8 points/relative	✓	4 points	6 points
Bilateral breast cancer	2 × related cancer	−	3 points	4 points/proband
Relatives included	Parents, siblings, children, grandparents, aunts/uncles, cousins, nieces/nephews, great grandparents, great aunts/uncles, distant cousins, other	Mother, sister, daughter, grandmothers, aunts, any male relative	Include all affected relatives to as far as third degree	Parents, siblings, children, grandparents, aunts, cousins, any male relative
Scoring	Obtain total for each lineage (paternal and maternal)	Positive or negative	Obtain family score based on each member of the women's extended family who had been diagnosed with breast, ovarian, colon, or prostate cancer; considering relationship of proband to affected individual, age of diagnosed and type/number of primary cancers (bilateral, multifocal, breast/ovarian); assess each lineage separately	Obtain an overall total
Threshold	≥8 points in either lineage	≥2 checks	≥10 points	≥6 points