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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Wiley Interdiscip Rev Membr Transp Signal. 2011 Oct 25;1(3):247–258. doi: 10.1002/wmts.17

Fig. 5. Proposed role for HVCN1 in ASL pH regulation.

Fig. 5

The CFTR HCO3- channel and the HVCN1 H+ channel provide a system for the regulation of the pH of the ASL. The ASL pH is the control variable to that governs H+ or HCO3- secretion into the ASL. An alkaline ASL pH activates HVCN1 and provides a driving force for H+ secretion. An acidic ASL pH provides a driving force for HCO3- secretion, however, requires additional activation of CFTR by the cAMP/PKA system. Arrow with circled + indicates activation. PKA, protein kinase A.