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Principal progressive phases in human PCa development.
| Definition | Acronyms | STAGE of PCa development | STAGE where CTCs could be possibly used |
|---|---|---|---|
| Proliferative Inflammatory Atrophy | PIA | Precursor of cancer initiation | YES |
| Prostatic Intraepithelial Neoplasia | MILD PIN | PreMalignancy | YES |
| HIGH PIN | Malignancy | YES | |
| Adenocarcinoma | WD | Well-differentiated Cancer | NO |
| PD | POOR differentiated Cancer | NO | |
| Fully Developed Metastatic Neoplasia | CRPC | Hormone refractory castration resistant Terminal cancer | NO |
