Fig. 5.

Effect of the SOD inhibitor diethyldithiocarbamate (DETC) on bradykinin-mediated vasodilation in coronary arterioles. DETC significantly attenuated dilation in nonoccluded (A) and collateral-dependent (B) arterioles of sedentary and exercise-trained pigs. Exercise-training-enhanced dilation in collateral-dependent arterioles was nearly reversed in the presence of DETC. In the presence of DETC, IC₅₀ values were similar in arterioles from the nonoccluded region of sedentary and exercise-trained pigs (A, inset). Treatment with DETC reversed the enhanced sensitivity to bradykinin that was observed under control conditions in arterioles from the collateral-dependent region of exercise-trained pigs (B, inset). Values are means ± SE of number of animals in parentheses. *P ≤ 0.05.