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Representative traces demonstrating the effect of endothelin-1 (ET-1) on intracellular calcium concentration ([Ca2+]i) in untreated cells (A) and after removal of extracellular Ca2+ (B) or treatment with nifedipine (C). D: bar graph representing means ± SE change in [Ca2+]i (Δ[Ca2+]i) in response to ET-1 under control conditions, after removal of extracellular Ca2+ (Ca2+-free) and in the presence of nifedipine. *Significant difference from control value.
