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Representative traces illustrating the effect of tyrosine kinase inhibition with genistein (Gen; A; 100 μM) and tyrphostin A23 (TA23; B; 100 μM) or combined blockade of PKC, Rho kinase, and tyrosine kinases (C) on ET-1-induced Δ[Ca2+]i. D: bar graph shows means ± SE Δ[Ca2+]i in control cells and cells treated with tyrosine kinase inhibitors and with a combination of Gen, Stauro (50 nM), and Y-27632 (10−5 M). *Significant difference from control value; †significant difference from zero.
