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. 2012 Jun 1;2(6):675–691. doi: 10.1534/g3.112.002279

Figure 9.

Figure 9

Genes regulated by the calcineurin pathway in C. glabrata. (A) List of 34 genes regulated by calcineurin and Crz1. There are 30 genes that were upregulated by calcineurin and Crz1, 3 genes downregulated by calcineurin and Crz1, and 1 gene (LIP5) upregulated by calcineurin but downregulated by Crz1. The criteria used to classify genes as upregulated or downregulated in the microarray experiments is a cutoff Q value < 0.001. (B) The transcription of CNA1 and CRZ1 was abolished in the cna1 (YC98) and crz1 (YC182) mutants, respectively. Real-time RT-PCR was used to measure the expression level of each gene. (C) Real-time RT-PCR was used to independently assess the expression levels detected in microarray analyses for YPS5 and RCN2 in wild-type, FK506-treated wild-type, cna1 mutant (YC98), and crz1 mutant (YC182). Statistically significant differences (P < 0.05 based on ANOVA, Bonferroni’s multiple comparison tests) compared with the wild-type are indicated by the asterisks.