Table 3.
Comparison of inflammatory cytokines, osteoprotegerin/receptor activator of NF-κB ligand axis, fetuin-A, and coronary artery calcification score between the progressive and nonprogressive groups
| Progressive (n=39) | Nonprogressive (n=39) | P Value | |
|---|---|---|---|
| IL-1β (baseline; pg/ml) | 0.90 (0.84–0.96) | 0.91 (0.86–1.00) | 0.36 |
| IL-6 (baseline; pg/ml) | 6.93 (3.38–10.38) | 6.93 (2.35–14.78) | 0.28 |
| TNF-α (baseline; pg/ml) | 33.1±10.6 | 32.6±9.3 | 0.83 |
| BAP (baseline; µg/L) | 22 (13–34) | 24 (12–42) | 0.65 |
| BAP (first year; µg/L) | 29 (18–52) | 25 (18–44) | 0.14 |
| RANKL (baseline; pmol/L) | 145 (104–244) | 147 (112–232) | 0.77 |
| RANKL (first year; pmol/L) | 100 (90–137) | 103 (97–148) | 0.65 |
| ∆RANKL (pmol/L) | 29 (−20–82) | 52 (5–82) | 0.70 |
| OPG (baseline; pmol/L) | 17.39±9.67 | 12.9±6.59 | 0.02 |
| OPG (first year; pmol/L) | 35.17±18.35 | 24±11.65 | 0.002 |
| ∆OPG (pmol/L) | 17.49±10.45 | 11.1±6.74 | 0.003 |
| OPG/RANKL (baseline) | 0.10 (0.04–0.26) | 0.06 (0.04–0.12) | 0.11 |
| OPG/RANKL (first year) | 0.26 (0.15–0.46) | 0.18 (0.12–0.28) | 0.004 |
| Fetuin A (baseline; g/L) | 1.34±0.34 | 1.31±0.36 | 0.72 |
| Fetuin A (first year; g/L) | 0.60±0.23 | 0.57±0.38 | 0.65 |
| CACS (baseline) | 178 (52–858) | 4 (0.3–200) | 0.18 |
| CACS (first year) | 495 (127–1,038) | 2.15 (0.82–72.8) | <0.001 |
For variables that are not normally distributed, median (interquartile range) was used. BAP, bone alkaline phosphatase; RANKL, receptor activator of NF-κB ligand; ∆RANKL, change in RANKL; OPG, osteoprotegerin; ∆OPG, change in OPG; CACS, coronary artery calcification score.