Table 1.
Baseline summary statistics
| Variable | Mean | SD | Median | First Quartile | Third Quartile |
|---|---|---|---|---|---|
| Age (yr) | 61.1 | 11.5 | 60.5 | 54.5 | 69 |
| Systolic BP (mmHg) | 143.4 | 17.51 | 143 | 130 | 154.5 |
| Diastolic BP (mmHg) | 75 | 10.1 | 71.5 | 66.5 | 84.5 |
| Body mass index (kg/m2) | 30.7 | 6.7 | 29.8 | 26.2 | 34.5 |
| HbA1c (%) | 8.3 | 2.2 | 7.6 | 6.8 | 9.7 |
| Glucose (mg/dl) | 135 | 76 | 109 | 92 | 161 |
| Total cholesterol (mg/dl) | 178 | 38 | 168 | 156 | 202 |
| HDL cholesterol (mg/dl) | 49 | 15 | 46 | 40 | 54 |
| LDL cholesterol (mg/dl) | 96 | 37 | 89 | 71 | 117 |
| Triglycerides (mg/dl) | 160 | 108 | 125 | 94 | 212 |
| Adiponectin (μg/ml) | 19.15 | 9.97 | 15.5 | 13 | 22.5 |
| Leptin (ng/ml) | 44.1 | 19.7 | 38.2 | 30.8 | 51.2 |
| High-sensitivity C-reactive protein (mg/L) | 10.1 | 12.2 | 6.95 | 1.8 | 10.4 |
| Intracellular TNFα (ng/mg protein) | 26.4 | 8.9 | 26.7 | 19.6 | 33.3 |
| 8-isoprostanes (pg/ml) | 288.7 | 99.6 | 249.7 | 223.6 | 316.7 |
| Serum carboxymethyllysine (U/ml) | 36.68 | 9.92 | 36.07 | 28.39 | 43.93 |
| Serum methylglyoxal (nmol/ml) | 3.21 | 0.91 | 3.33 | 2.26 | 3.87 |
| Intracellular carboxymethyllysine (U/mg protein) | 9.99 | 2.21 | 9.49 | 8.5 | 11.23 |
| Intracellular methylglyoxal (nmol/mg protein) | 1.61 | 0.56 | 1.52 | 1.14 | 1.78 |
| AGER1 (mRNA) | 86.8 | 34.5 | 84.5 | 64 | 110 |
| SIRT1 (mRNA) | 159.8 | 62.4 | 163.5 | 104.5 | 211 |
| Cystatin C (mg/L) | 1.86 | 0.74 | 1.76 | 1.1 | 2.63 |
| Estimated GFR (ml/min per 1.73 m2) | 38.1 | 22.1 | 30.1 | 21.7 | 49.9 |
| Serum potassium (mmol/L) | 4.42 | 0.71 | 4.5 | 3.5 | 5.05 |
| Serum phosphate (mg/dl) | 4.02 | 0.74 | 3.8 | 3.45 | 4.55 |
| Serum chloride (mmol/L) | 101.45 | 3.14 | 101.5 | 99 | 103.5 |
| Serum bicarbonate (mmol/L) | 24.9 | 2.9 | 24.5 | 23.2 | 26.8 |
| Fibroblast growth factor 23 (μg/ml) | 94.95 | 98.18 | 52.45 | 32.25 | 101.65 |
| Urine phosphate (g/d) | 0.58 | 0.31 | 0.6 | 0.36 | 0.8 |
| Urine phosphate/creatinine (g/g) | 0.51 | 0.21 | 0.49 | 0.38 | 0.58 |
| Urine protein/creatinine (mg/mg) | 1.77 | 2.65 | 0.8 | 0.44 | 1.61 |
| Dietary phosphate (mg/d) | 967 | 479 | 863 | 651 | 1326 |
AGER1, advanced glycation end product receptor 1; SIRT1, sirtuin 1.