Table 2.
Summary statistics for deltas (last minus first visit), by treatment
| Calcium Carbonate | Sevelamer Carbonate | |||||||
|---|---|---|---|---|---|---|---|---|
| n | Mean | SD | P Value | n | Mean | SD | P Value | |
| Body mass index (kg/m2) | 20 | −0.12 | 0.9 | 0.73 | 20 | −0.08 | 1.12 | 0.73 |
| HbA1c (%) | 20 | −0.07 | 0.81 | 0.99 | 18 | −0.74 | 0.89 | 0.002 |
| Glucose (mg/dl) | 20 | 14.8 | 48.79 | 0.23 | 20 | −20.55 | 85.53 | 0.34 |
| Total cholesterol (mg/dl) | 20 | 2.85 | 31.19 | 0.81 | 19 | −13.84 | 34.34 | 0.08 |
| HDL cholesterol (mg/dl) | 20 | −0.6 | 6.37 | 0.73 | 19 | 1.79 | 10.87 | 0.19 |
| LDL cholesterol (mg/dl) | 20 | 2.8 | 28.4 | 0.85 | 19 | −8.74 | 28.82 | 0.21 |
| Triglycerides (mg/dl) | 20 | 21.7 | 75.4 | 0.59 | 19 | −32.95 | 61.3 | 0.02 |
| Adiponectin (µg/ml) | 20 | −1.4 | 3.5 | 0.16 | 20 | −0.85 | 2.06 | 0.10 |
| Leptin (ng/ml) | 20 | 0.6 | 6.71 | 0.41 | 20 | −4.56 | 12.14 | 0.02 |
| High-sensitivity C-reactive protein (mg/ml) | 20 | 0.29 | 3.88 | 0.81 | 20 | −1.68 | 15.04 | 0.28 |
| Intracellular TNFα (ng/mg protein) | 20 | 0.11 | 4.79 | 0.93 | 20 | −7.08 | 8.3 | 0.002 |
| 8-isoprostanes (pg/ml) | 20 | 34.1 | 69 | 0.04 | 20 | −69.75 | 109.92 | 0.003 |
| Serum carboxymethyllysine (U/ml) | 20 | 2.87 | 9.15 | 0.41 | 20 | −8.24 | 10.86 | 0.006 |
| Serum methylglyoxal (nmol/ml) | 20 | 0.11 | 0.5 | 0.56 | 20 | −0.44 | 0.91 | 0.02 |
| Intracellular carboxymethyllysine (U/mg protein) | 17 | 0.41 | 1.95 | 0.52 | 17 | −1.96 | 2.92 | 0.03 |
| Intracellular methylglyoxal (nmol/mg protein) | 17 | 0.1 | 0.38 | 0.33 | 17 | −0.35 | 0.67 | 0.02 |
| AGER1 (mRNA) | 20 | −6.65 | 41.04 | 0.96 | 20 | 114.00 | 126.60 | 0.001 |
| SIRT1 (mRNA) | 20 | −3.5 | 56.78 | 0.58 | 20 | 89.45 | 104.51 | <0.001 |
| Cystatin C (mg/L) | 18 | 0.02 | 0.26 | 0.93 | 19 | 0.013 | 0.56 | 0.89 |
| Estimated GFR (ml/min per 1.73 m2) | 20 | −0.32 | 10.73 | 0.98 | 19 | 1.45 | 5.39 | 0.39 |
| Serum potassium (mmol/L) | 20 | −0.22 | 0.60 | 0.16 | 20 | 0.24 | 0.57 | 0.07 |
| Serum phosphate (mg/dl) | 20 | −0.26 | 0.7 | 0.10 | 19 | 0.02 | 0.86 | 0.62 |
| Serum chloride (mmol/L) | 20 | −1.45 | 3.52 | 0.08 | 20 | 1.45 | 4.31 | 0.19 |
| Serum bicarbonate (mmol/L) | 20 | 1.45 | 3.72 | 0.09 | 20 | −0.05 | 3.65 | 0.85 |
| Fibroblast growth factor 23 (µg/ml) | 20 | 30 | 95 | 0.17 | 20 | −30 | 64 | 0.08 |
| Urine phosphate (g/d) | 20 | −0.18 | 0.23 | 0.002 | 20 | −0.1 | 0.23 | 0.03 |
| Urine phosphate/creatinine (g/g) | 19 | −0.13 | 0.19 | 0.01 | 19 | −0.14 | 0.35 | 0.18 |
| Urine protein/creatinine (mg/mg) | 19 | 0.02 | 0.84 | 0.48 | 19 | 0.04 | 1.01 | 0.84 |
| Dietary phosphate (mg/d) | 18 | −112 | 582 | 0.13 | 20 | −143 | 489 | 0.55 |
AGER1, advanced glycation end product receptor 1; SIRT1, sirtuin 1.