Fig. 4.
Effect of changing the subunit stoichiometry of Hco-L-AChR1 on cholinergic agonist responses. a Amplitude of inward currents elicited by Ach (100 μM), levamisole (Lev, 30 μM), bephenium (Beph, 30 μM) and pyrantel (Pyr, 30 μM) on oocytes injected with Hco-L-AChR1 encoding mix or cRNA mixes containing five fold of Hco-unc-38, Hco-unc-63, Hco-acr-8 cRNAs, respectively. The number of oocytes recorded for each conditions is ranging from 3 to 42 displayed on 3 batches of oocytes. b Relative efficacy of cholinergic agonists on oocytes injected with L-AChR1 encoding mix or cRNA mixes containing five fold of Hco-unc-38, Hco-unc-63, Hco-acr-8 cRNAs, respectively. All values are normalized to the current elicited by application of 100 μM Ach