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. 2011 Dec 21;3(3):607–612. doi: 10.3892/ol.2011.531

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Role of epidermal growth factor (EGF)/epidermal growth factor receptor (EGFR) signaling in sphere-forming activity of MCF7 cells. (A and B) Sphere-forming assay of MCF7 cells (upper panels) and A549 (lower panels) with or without GFs in the presence or absence of EGFR inhibitors (A) gefitinib and (B) AG1478. (C and D) Sphere-forming activity of MCF7 cells (upper panels) and A549 cells (lower panels) without GFs with or without treatment with neutralizing antibodies anti-EGF (C) and anti-bFGF (D). Data are presented as the means ± SD. ^*p<0.01, sphere-forming activity compared with untreated control.

Role of epidermal growth factor (EGF)/epidermal growth factor receptor (EGFR) signaling in sphere-forming activity of MCF7 cells. (A and B) Sphere-forming assay of MCF7 cells (upper panels) and A549 (lower panels) with or without GFs in the presence or absence of EGFR inhibitors (A) gefitinib and (B) AG1478. (C and D) Sphere-forming activity of MCF7 cells (upper panels) and A549 cells (lower panels) without GFs with or without treatment with neutralizing antibodies anti-EGF (C) and anti-bFGF (D). Data are presented as the means ± SD. ^*p<0.01, sphere-forming activity compared with untreated control.