Table II.
A, Acute systemic toxicity during CCRT. | |||
---|---|---|---|
Non-extended field n=18 (%) |
Extended field n=19 (%) |
p-value | |
≥4 cycles of CDDP | 14 (78) | 13 (68) | 0.713 |
Number of patients with grade 3–4 acute toxicity | |||
Hematologic toxicity | 8 (44) | 12 (63) | 0.121 |
Leukopenia | 7 (38) | 11 (58) | |
Thrombocytopenia | 0 (0) | 0 (0) | |
Anemia | 1 (5.3) | 3 (16) | |
Gastrointestinal toxicity | 1 (5.3) | 4 (22) | 0.153 |
B, Acute systemic toxicity during adjuvant chemotherapy. | |||
---|---|---|---|
Non-extended field n=4 (%) |
Extended field n=13 (%) |
p-value | |
Number of patients with grade 3–4 acute hematologic toxicity | 4 (100) | 13 (100) | NS |
Leukopenia | 4 (100) | 12 (92) | |
Thrombocytopenia | 0 (0) | 3 (23) | |
Anemia | 0 (0) | 7 (54) |
C, Late treatment-related toxicities. | ||||
---|---|---|---|---|
CCRT-alone (n=20) | CCRT-CTX (n=17) | |||
Grade 1–2 | Grade 3–5 | Grade 1–2 | Grade 3–5 | |
Site of effect | ||||
Gastrointestinal | 3 | 1 | 2 | 1 |
Genitourinary | 0 | 0 | 1 | 0 |
Insufficiency fractures | 1 | 0 | 2 | 0 |