Table I.
Clinical profiling of 9 mCRC patients and their biomarker status.
| Characteristic | Case 1 | Case 2 | Case 3 | Case 4 | Case 5 | Case 6 | Case 7 | Case 8 | Case 9 |
|---|---|---|---|---|---|---|---|---|---|
| Age | 72 | 66 | 65 | 56 | 67 | 75 | 71 | 72 | 57 |
| Gender | M | M | M | F | M | F | M | M | F |
| Primary | R | A | R | A | A | A | A | T | S |
| Hist | Wel-mod | Mod | Mod>wel | Mod | Mod | Wel | Mod | Wel | Wel>mod |
| Meta | Liver | Liver | Liver | Liver | Liver | Liver | Lung | Liver | Ovary |
| Lung | Lung | LN | |||||||
| Occurence | S | S | M | S | S | M | M | M | S |
| M | S | M | |||||||
| Interval (D) | - | - | 483 | - | - | 382 | 1652 | 2321 | - |
| 1435 | - | 2321 | |||||||
| KRAS | G13D | Wild | Wild | Wild | G12D | Wild | Wild | Wild | Wild |
| G13D | Wild | Wild | Wild | G12D | Wild | Wild | G12V | Wild | |
| Wild | G12D | G12V | |||||||
| BRAF | Wild | Wild | Wild | Wild | Wild | Wild | L597R | Wild | Wild |
| Wild | Wild | Wild | Wild | Wild | Wild | L597R | Wild | Wild | |
| Wild | Wild | ND | |||||||
| PIK3CA | Wild | Wild | Wild | Q546E | Wild | Wild | Wild | Wild | Wild |
| Wild | Wild | Wild | Q546E | Wild | Wild | Wild | Wild | Wild | |
| Wild | Wild | ND | |||||||
| EGFR | (−) | (+) | (+) | (+) | (−) | (−) | (−) | (−) | (+) |
| (−) | (+) | (+) | (+) | (−) | (−) | (+) | (+) | (+) | |
| (+) | (−) | ND | |||||||
| GSTP | (+++) | (+++) | (+++) | (+++) | (++) | (−) | (+) | (−) | (−) |
| (++) | (++) | (++) | (+++) | (+++) | (−) | ND | (−) | (−) | |
| ND | ND | ND |
S, synchronous metastasis; M, metachronous metastasis; Wel, well-differentiated; Mod, moderately differentiated; ND, non-defined. Interval indicates days between primary and metastatic lesion resection. CRC, colorectal cancer; LN, lymph node; GSTP, glutathione S-transferase II; EGFR, epidermal growth factor receptor; R, rectal; A, ascending; T, transverse; S, sigmoid.