Table III.
Genotype and allele frequencies of the hMLH1 and hMSH2 polymorphisms among cases and controls and the association with risk of gastric cancer.
| Genotype | Cases (n=554) n (%) | Controls (n=592) n (%) | Pb | Adjusted OR (95% CI)b |
|---|---|---|---|---|
| hMLH1 | ||||
| -93G>Aa | ||||
| GG | 104 (18.8) | 124 (21.1) | 1.00 (reference) | |
| GA | 262 (47.3) | 271 (46.1) | 0.598 | 1.09 (0.79–1.51) |
| AA | 188 (33.9) | 193 (32.8) | 0.368 | 1.17 (0.83–1.65) |
| GA+AA | 450 (81.2) | 464 (78.9) | 0.450 | 1.12 (0.83–1.52) |
| A allele | 0.576 | 0.559 | 0.313c | |
| I219V | ||||
| AA | 522 (94.2) | 568 (95.9) | 1.00 (reference) | |
| AG+GGd | 32 (5.8) | 24 (4.1) | 0.129 | 1.54 (0.88–2.67) |
| G allele | 0.030 | 0.021 | 0.187c | |
| hMSH2 | ||||
| IVS12-6C>Ta | ||||
| CC | 64 (11.6) | 73 (12.3) | 1.00 (reference) | |
| CT | 258 (46.7) | 279 (47.1) | 0.631 | 1.10 (0.74–1.64) |
| TT | 230 (41.7) | 240 (40.6) | 0.569 | 1.12 (0.75–1.68) |
| CT+TT | 488 (88.4) | 519 (87.7) | 0.581 | 1.11 (0.76–1.63) |
| C allele | 0.650 | 0.641 | 0.728c | |
| -118T>Ca | ||||
| TT | 367 (66.9) | 422 (71.4) | 1.00 (reference) | |
| TC | 163 (29.7) | 154 (26.1) | 0.169 | 1.21 (0.92–1.59) |
| CC | 19 (3.4) | 15 (2.5) | 0.383 | 1.39 (0.67–2.89) |
| TC+CC | 182 (33.1) | 169 (28.6) | 0.128 | 1.23 (0.94–1.60) |
| C allele | 0.183 | 0.156 | 0.096c | |
a
Genotypes were less than the total number (554 cases, 592 controls) since some genotypes were undetermined.
b
Adjusted for age, gender, smoking status and alcohol use in the logistic regression model.
c
Two-sided χ2-test for the differences in the minor allele frequencies between cases and controls.
d
Heterozygous (AG) and homozygous (GG) variants were collapsed due to the low variant G allele frequency.