Table IV.
Stratification analyses between hMSH2 -118T>C genotypes and risk of gastric cancer in cases and controls.
| Variables | Cases/controls | Genotype (cases/controls) | Pc | Adjusted OR (95% CI)c TC+CC vs TT |
|||
|---|---|---|---|---|---|---|---|
| TT | TC+CC | ||||||
| n | % | n | % | ||||
| Totala | 549/591 | 367/422 | 66.8/71.4 | 182/169 | 33.2/28.6 | 0.128 | 1.23 (0.94–1.60) |
| Age (years) | |||||||
| ≤63 | 297/298 | 185/208 | 62.3/69.8 | 112/90 | 37.7/30.2 | 0.026 | 1.51 (1.05–2.16) |
| >63 | 252/293 | 182/214 | 72.2/73.0 | 70/79 | 27.8/27.0 | 0.961 | 0.99 (0.66–1.48) |
| Gender | |||||||
| Male | 374/390 | 258/281 | 69.0/72.0 | 116/109 | 31.0/28.0 | 0.355 | 1.17 (0.84–1.63) |
| Female | 175/201 | 109/141 | 62.3/70.1 | 66/60 | 37.7/29.9 | 0.120 | 1.44 (0.91–2.28) |
| Smoking statusb | |||||||
| Never | 280/412 | 190/292 | 67.9/70.9 | 90/120 | 32.1/29.1 | 0.441 | 1.14 (0.82–1.60) |
| Regular | 228/172 | 151/126 | 66.2/73.3 | 77/46 | 33.8/26.7 | 0.142 | 1.39 (0.90–2.16) |
| Alcohol useb | |||||||
| Never | 338/437 | 227/316 | 67.2/72.3 | 111/121 | 32.8/27.7 | 0.154 | 1.26 (0.92–1.72) |
| Regular | 166/146 | 110/101 | 66.3/69.2 | 56/45 | 33.7/30.8 | 0.689 | 1.11 (0.67–1.84) |
a
Genotypes were less than the total number (554 cases, 592 controls) since some genotypes were undetermined.
b
The numbers of subjects in cases or controls were less than the total number (554 cases, 592 controls) as certain information could not be obtained.
c
Adjusted for age, gender, smoking status and alcohol use in the logistic regression model.