Figure 1.
Change in the percentage composition of SN-38 glucuronide during the course of incubation in 10-fold diluted cecal content culture. SN-38 glucuronide was added to the culture medium and incubated anaerobically with N2 for up to 72 h. Dark blue, SN-38 glucuronide in pelleted fraction; light blue, SN-38 glucuronide in supernatant; red, SN-38 lactone in pelleted fraction; pink, SN-38 lactone in supernatant; dark green, SN-38 carboxylate in pelleted fraction; light green, SN-38 carboxylate in supernatant.